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Perturbation of protein kinase CK2 uncouples executive part of phosphate maintenance pathway from cyclin‐CDK control 1
Author(s) -
Barz Thomas,
Ackermann Karin,
Pyerin Walter
Publication year - 2003
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)00112-1
Subject(s) - cyclin dependent kinase , microbiology and biotechnology , cyclin dependent kinase complex , cyclin dependent kinase 2 , biology , cyclin , biochemistry , chemistry , protein kinase a , kinase , cell cycle , gene
The budding yeast Saccharomyces cerevisiae encounters phosphate starvation by the transcription‐regulated PHO pathway. We find that genetic perturbation of protein kinase CK2, a conserved tetrameric Ser/Thr phosphotransferase with links to cell cycle and transcription, affects expression of PHO pathway genes in a subunit‐ and isoform‐specific manner. Remarkably, the genes encoding phosphate supplying phosphatases and transporters are significantly repressed, while the genes encoding components of the central pathway regulator complex, a cyclin‐dependent kinase (CDK), a cyclin, and a CDK inhibitor, remain unaltered. Thus, perturbation of CK2 uncouples the executive part of the PHO pathway from its cyclin‐CDK control complex.