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Complement component anaphylatoxins upregulate chemokine expression by human astrocytes
Author(s) -
Jauneau Anne-Christine,
Ischenko Alexander,
Chan Philippe,
Fontaine Marc
Publication year - 2003
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)00060-7
Subject(s) - anaphylatoxin , chemokine , cxcl2 , proinflammatory cytokine , complement system , immunology , biology , microbiology and biotechnology , chemokine receptor , immune system , inflammation
The complement (C) system, a major component of the innate immune system, has been described as a factor implicated in some brain disorders. C activation leads to the release of anaphylatoxins, two proinflammatory polypeptides acting through specific receptors that have been detected on brain cells. Here, we examined the effect of anaphylatoxins on chemokine expression by human astrocytes. We showed that anaphylatoxins significantly increase chemokine mRNA expression. However, anaphylatoxin‐induced chemokine secretion (interleukin‐8) was observed only in the presence of interleukin‐1β. Thus, anaphylatoxins could initiate a chemokine cascade and, at least in part, be involved in pathogenesis of the brain.