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Mitochondrial ATP‐sensitive K + channel opening decreases reactive oxygen species generation
Author(s) -
Ferranti Renato,
da Silva Mirian M,
Kowaltowski Alicia J
Publication year - 2003
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(03)00007-3
Subject(s) - reactive oxygen species , mitochondrion , oxidative phosphorylation , oxygen , respiration , membrane potential , adenosine triphosphate , atp synthase , biophysics , inner mitochondrial membrane , chemistry , biochemistry , microbiology and biotechnology , biology , anatomy , enzyme , organic chemistry
Mitochondrial ATP‐sensitive K + channel (mitoK ATP ) opening was shown previously to slightly increase respiration and decrease the membrane potential by stimulating K + cycling across the inner membrane. Here we show that mitoK ATP opening reduces reactive oxygen species generation in heart, liver and brain mitochondria. Decreased H 2 O 2 release is observed when mitoK ATP is active both with respiration stimulated by oxidative phosphorylation and when ATP synthesis is inhibited. In addition, decreased H 2 O 2 release is observed when mitochondrial ΔpH is enhanced, an effect expected to occur when mitoK ATP is open. We conclude that mitoK ATP is an effective pathway to trigger mild uncoupling, preventing reactive oxygen species release.