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Alternative splicing of myeloid IgA Fc receptor (FcαR, CD89) transcripts in inflammatory responses
Author(s) -
Togo Shinsaku,
Shimokawa Toshibumi,
Fukuchi Yoshinosuke,
Ra Chisei
Publication year - 2003
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(02)03891-7
Subject(s) - splice , receptor , myeloid , immunology , alternative splicing , delta , fc receptor , alpha (finance) , tumor necrosis factor alpha , biology , antibody , chemistry , microbiology and biotechnology , gene , medicine , messenger rna , genetics , patient satisfaction , engineering , aerospace engineering , construct validity , nursing
More than 10 splice variants of the Fc receptor for IgA (FcαR, CD89) have been identified in human myeloid cells. In this study, we quantified FcαR splice transcripts ΔEC2 and Δ66EC2, which lack the entire and a part of the homologous immunoglobulin‐like extracellular domain 2 (EC2), respectively. Tumor necrosis factor‐α was found to specifically increase the ratio of ΔEC2 to the wild type CD89 in neutrophils and conversely decrease the ΔEC2 ratio in monocytes. We also observed a significant decrease in the neutrophil ΔEC2/CD89 ratio in pneumonia patients. These results suggest that ΔEC2 is differentially regulated and could be involved in immunoregulation of IgA‐mediated host defense.