Premium
Diversity of the human erythrocyte membrane sialic acids in relation with blood groups
Author(s) -
Bulai Tatiana,
Bratosin Daniela,
Pons Alexandre,
Montreuil Jean,
Zanetta Jean-Pierre
Publication year - 2003
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(02)03838-3
Subject(s) - sialic acid , erythrocyte membrane , chemistry , diversity (politics) , biochemistry , membrane , sociology , anthropology
The composition of the human erythrocyte membrane (RBC) glycoprotein‐ and glycolipid‐bound sialic acids of A, B, AB and O type donors was studied using a new method (Zanetta et al., Glycobiology 11 (2001) 663–676). In addition to Neu5Ac as the major compound, Kdn, Neu5,9Ac 2 , Neu5,7Ac 2 , Neu (de‐ N ‐acetylated‐Neu5Ac), Neu5Ac8Me, Neu5Ac9Lt, Neu4,5Ac 2 , Neu5,8Ac 2 9Lt and Neu5Ac8S were characterised. Among these different compounds, Neu5Ac8Me, Neu5Ac9Lt, Neu4,5Ac 2 , Neu5,8Ac 2 9Lt and Neu5Ac8S have never been described and quantitatively determined before in human tissues or cells. Neu5Gc and its O ‐alkylated or O ‐acylated derivatives were not detected.