Premium
Identification of 30 protein species involved in replicative senescence and stress‐induced premature senescence
Author(s) -
Dierick Jean-François,
Kalume Dário E,
Wenders Frédéric,
Salmon Michel,
Dieu Marc,
Raes Martine,
Roepstorff Peter,
Toussaint Olivier
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(02)03604-9
Subject(s) - senescence , microbiology and biotechnology , biology , identification (biology) , cellular senescence , genetics , phenotype , botany , gene
Exposure of human proliferative cells to subcytotoxic stress triggers stress‐induced premature senescence (SIPS) which is characterized by many biomarkers of replicative senescence. Proteomic comparison of replicative senescence and stress‐induced premature senescence indicates that, at the level of protein expression, stress‐induced premature senescence and replicative senescence are different phenotypes sharing however similarities. In this study, we identified 30 proteins showing changes of expression level specific or common to replicative senescence and/or stress‐induced premature senescence. These changes affect different cell functions, including energy metabolism, defense systems, maintenance of the redox potential, cell morphology and transduction pathways.