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New potent inhibitors of aquaporins: silver and gold compounds inhibit aquaporins of plant and human origin
Author(s) -
Niemietz Christa M,
Tyerman Stephen D
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(02)03581-0
Subject(s) - aquaporin , chemistry , membrane , biochemistry , biophysics , membrane permeability , biology
Silver and gold compounds were tested as potential inhibitors of aquaporins of plant‐ and human origin. Silver as AgNO 3 or silver sulfadiazine inhibited with high potency (EC 50 1–10 μM) the water permeability of the peribacteroid membrane from soybean (containing Nodulin 26), the water permeability of plasma membrane from roots (containing plasma membrane integral proteins), and the water permeability of human red cells (containing aquaporin 1). Gold as HAuCl 4 was less effective but still inhibited peribacteroid membrane water permeability (EC 50 =10 μM). Silver and gold are more potent inhibitors of aquaporins than the presently widely used mercury containing compounds.