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Expression and regulation of peroxiredoxin 5 in human osteoarthritis
Author(s) -
Wang Min-Xia,
Wei Aiqun,
Yuan Jun,
Trickett Annette,
Knoops Bernard,
Murrell George A.C
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(02)03511-1
Subject(s) - peroxiredoxin , oxidative stress , thioredoxin , cartilage , reactive oxygen species , osteoarthritis , microbiology and biotechnology , tumor necrosis factor alpha , pathogenesis , chemistry , biology , peroxidase , immunology , medicine , biochemistry , pathology , anatomy , enzyme , alternative medicine
Reactive oxygen species (ROS) are implicated in the pathogenesis of osteoarthritis (OA). However, little is known about the antioxidant defence system in articular cartilage. We investigated the expression and regulation of peroxiredoxin 5 (PRDX5), a newly discovered thioredoxin peroxidase, in human normal and osteoarthritic cartilage. Our results show that human cartilage constitutively expresses PRDX5. Moreover, the expression is up‐regulated in OA. Inflammatory cytokines tumour necrosis factor α and interleukin 1 β contribute to this up‐regulation by increasing intracellular ROS production. The present study suggests that PRDX5 may play a protective role against oxidative stress in human cartilage.