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Expression and function of phospholipase A 2 in brain
Author(s) -
Balboa Marı́a A,
Varela-Nieto Isabel,
Killermann Lucas Karin,
Dennis Edward A
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(02)03481-6
Subject(s) - phospholipase a2 , arachidonic acid , cyclooxygenase , lipopolysaccharide , inflammation , phospholipase , chemistry , phospholipase a , function (biology) , eicosanoid , prostaglandin , central nervous system , microbiology and biotechnology , cell , nervous system , prostaglandin e2 , prostaglandin e , endocrinology , biochemistry , immunology , neuroscience , enzyme , biology
Phospholipase A 2 (PLA 2 ) appears to play a fundamental role in cell injury in the central nervous system. We have investigated PLA 2 expression in the astrocytoma cell line 1231N1, and found that GIVA, GIVB, GIVC and GVI PLA 2 messages are expressed. PLA 2 activity is increased by inflammatory/injury stimuli such as interleukin‐1β and lipopolysaccharide in these cells but with very different time courses. The arachidonic acid liberated is converted to prostaglandin E 2 , possibly by cyclooxygenase‐2, which is induced by inflammatory stimuli. This cell system emerges as a model to study injury/inflammation‐related activation of the new PLA 2 forms GIVB and GIVC.