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Mitogen‐inducible gene 6 (MIG‐6), adipophilin and tuftelin are inducible by hypoxia
Author(s) -
Saarikoski Sirkku T,
Rivera Steven P,
Hankinson Oliver
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(02)03475-0
Subject(s) - aryl hydrocarbon receptor nuclear translocator , hypoxia (environmental) , gene , hypoxia inducible factor 1 , carcinogenesis , hypoxia inducible factors , biology , pas domain , microbiology and biotechnology , cancer research , chemistry , regulation of gene expression , transcription factor , genetics , oxygen , organic chemistry , aryl hydrocarbon receptor
Adaptation to hypoxia is essential for tumor progression. Transcriptional activation of hypoxia‐regulated genes is mediated by hypoxia‐inducible factor 1 (HIF‐1), a heterodimer of HIF‐1α and ARNT (Ah receptor nuclear translocator; HIF‐1β). Using representational difference analysis, we identified three novel hypoxia‐inducible genes: MIG‐6 (gene 33), adipophilin and tuftelin. The mRNAs for these genes were inducible by 1% O 2 in the human HepG2 and MCF‐7 cell lines. Hypoxic induction of the MIG‐6 and tuftelin proteins was also observed. Induction was ARNT‐dependent. Induction also occurred in livers of mice treated with CoCl 2 , which mimics hypoxia. The potential roles of these genes in adaptation to hypoxia and in tumorigenesis will be of considerable interest.