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Lipopolysaccharide increases resistin gene expression in vivo and in vitro
Author(s) -
Lu Shao-Chun,
Shieh Wei-Yeong,
Chen Chia-Ying,
Hsu Shu-Ching,
Chen Hui-Ling
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(02)03450-6
Subject(s) - resistin , lipopolysaccharide , medicine , endocrinology , insulin resistance , adipose tissue , in vivo , white adipose tissue , inflammation , diabetes mellitus , in vitro , biology , adipokine , biochemistry , microbiology and biotechnology
Although resistin has been thought to be an important link between obesity and diabetes, recent results do not support this hypothesis. We speculated that resistin may be involved in inflammatory processes and be induced by inflammatory stimuli. In this study, we tested whether lipopolysaccharide (LPS) induced resistin expression in rats. The results show that resistin mRNA levels in white adipose tissue and white blood cells were increased by LPS treatment. LPS also increased resistin mRNA levels in 3T3‐L1 adipocytes and human peripheral blood monocytes. The results suggest that resistin is involved in insulin resistance and probably in other inflammatory responses.