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Induction of human inhibitor of apoptosis protein‐2 by shear stress in endothelial cells
Author(s) -
Jin Xin,
Mitsumata Masako,
Yamane Tetsu,
Yoshida Yoji
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(02)03361-6
Subject(s) - apoptosis , shear stress , chemistry , microbiology and biotechnology , biology , biochemistry , materials science , composite material
To disclose the anti‐atherosclerotic mechanisms of steady laminar shear stress, we analyzed the expression of human inhibitor of apoptosis protein‐2 (HIAP‐2), whose gene was selected from a cDNA library of sheared endothelial cells (ECs), on ECs. HIAP‐2 was dose‐independently and time‐dependently induced in ECs by shear stress, regulated at the transcriptional level. HIAP‐2 expression was also identified in vivo. Shear stress‐mediated inhibition of EC apoptosis was associated with the inhibition of caspase‐3 activity, suggesting that the shear stress prevents EC apoptosis via negative regulation of caspase‐3 by the increment of HIAP‐2.