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Nitric oxide synthesis is involved in arterial haptoglobin expression after sustained flow changes
Author(s) -
Smeets Mirjam B,
Pasterkamp Gerard,
Lim Sai-Kiang,
Velema Evelyn,
van Middelaar Ben,
de Kleijn Dominique P.V
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(02)03343-4
Subject(s) - haptoglobin , medicine , endocrinology , nitric oxide , acute phase protein , autoregulation , biology , chemistry , immunology , blood pressure , inflammation
The acute phase protein haptoglobin is highly expressed in arteries after sustained flow changes and involved in cell migration and arterial restructuring. In the liver, haptoglobin expression is mainly regulated by interleukin‐6 (IL‐6). In the artery, shear stress and NO influence IL‐6 expression. In the present study, we demonstrate that NO synthesis is involved in the regulation of arterial haptoglobin expression after sustained flow changes. Decreased haptoglobin expression after NO inhibition coincided with decreased IL‐6 levels. However, IL‐6 knockout mice had normal arterial haptoglobin expression levels after sustained flow changes suggesting that other mediators may provide compensatory mechanisms for the regulation of arterial haptoglobin expression.