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Vitamin E sensitive genes in the developing rat fetal brain: a high‐density oligonucleotide microarray analysis
Author(s) -
Roy Sashwati,
Lado Beatrice H,
Khanna Savita,
Sen Chandan K
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(02)03309-4
Subject(s) - fetus , microarray , vitamin e , tocotrienol , microarray analysis techniques , dna microarray , neuroprotection , gene chip analysis , biology , vitamin , gene expression , bioavailability , gene , endocrinology , pregnancy , tocopherol , pharmacology , biochemistry , genetics , antioxidant
Vitamin E (tocopherols and tocotrienols) is essential for normal neurological function. Recently we have reported that the neuroprotective properties of tocotrienols are much more potent than that of the widely studied tocopherols (Sen, C.K., Khanna, S., Roy, S. and Parker, L. (2000) J. Biol. Chem. 275, 13049–13055). The objective of this study was to evaluate whether (i) oral supplementation of tocotrienols during pregnancy is bioavailable to fetal and mother brains; (ii) short‐term change in dietary vitamin E levels of pregnant rats influences gene expression profile of developing fetal brains. We report that dietary tocotrienol is bioavailable to both mother and fetal brains. The enrichment is more in fetal brain tissue. Using a GeneChip microarray expression profiling approach we have identified a specific set of vitamin E sensitive genes in the developing rat fetal brain.