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E2F1 pathways to apoptosis
Author(s) -
Ginsberg Doron
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(02)03270-2
Subject(s) - e2f1 , apoptosis , microbiology and biotechnology , e2f , suppressor , cell growth , cancer research , transcription factor , programmed cell death , cell cycle , biology , cancer , genetics , gene
The E2F family of transcription factors plays a pivotal role in the regulation of cell proliferation and their activity is often deregulated in human tumors. Recent studies demonstrate that E2F1 can induce both proliferation and apoptosis. E2F1‐induced apoptosis occurs via multiple pathways, some of which induce stabilization and activation of the tumor suppressor p53. The pro‐apoptotic activity of E2F1 suggests that its deregulation constitutes an oncogenic stress that may target pre‐malignant cells to undergo apoptosis, thus preventing tumor development.