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Stabilization signals: a novel regulatory mechanism in the ubiquitin/proteasome system
Author(s) -
Dantuma Nico P,
Masucci Maria G
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(02)03252-0
Subject(s) - ubiquitin , proteasome , degradation (telecommunications) , protein degradation , microbiology and biotechnology , mechanism (biology) , chemistry , domain (mathematical analysis) , protein turnover , signal (programming language) , biophysics , computational biology , biology , biochemistry , computer science , physics , protein biosynthesis , gene , mathematics , telecommunications , mathematical analysis , quantum mechanics , programming language
The turnover of cellular proteins is a highly organized process that involves spatially and temporally regulated degradation by the ubiquitin/proteasome system. It is generally acknowledged that the specificity of the process is determined by constitutive or conditional protein domains, the degradation signals, that target the substrate for proteasomal degradation. In this review, we discuss a new type of regulatory domain: the stabilization signal. A model is proposed according to which protein half‐lives are determined by the interplay of counteracting degradation and stabilization signals.