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The eye photoreceptor protein rhodopsin. Structural implications for retinal disease 1
Author(s) -
Garriga Pere,
Manyosa Joan
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(02)03241-6
Subject(s) - rhodopsin , visual phototransduction , retinal , structural motif , biology , transmembrane protein , signal transduction , transmembrane domain , retina , transducin , g protein coupled receptor , microbiology and biotechnology , receptor , neuroscience , biochemistry
Rhodopsin is the membrane receptor responsible for photoreception in the vertebrate retina. Its characteristic seven‐transmembrane helical structural motif is today widely recognised as a paradigm in signal transduction. Rhodopsin and the phototransduction system are frequently used as structural and mechanistic models for the G‐protein coupled receptor superfamily. Recent advances in the activation mechanism (as derived from the structural available data) and the implications for normal and pathological – in retinal disorders – visual function will be reviewed.