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CIN85/CMS family of adaptor molecules
Author(s) -
Dikic Ivan
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(02)03188-5
Subject(s) - signal transducing adaptor protein , endocytic cycle , microbiology and biotechnology , clathrin adaptor proteins , signal transduction , cytoskeleton , biology , actin cytoskeleton , receptor tyrosine kinase , function (biology) , chemistry , receptor , cell , biochemistry , endocytosis
CIN85 and CMS belong to a family of ubiquitously expressed adaptor molecules containing three SH3 domains, a proline‐rich region and a coiled‐coil domain. By binding to numerous proteins they assemble multimeric complexes implicated in cell‐specific signals controlling T‐cell activation, kidney glomeruli function or apoptosis in neuronal cells. CIN85/CMS also associate with accessory endocytic proteins, components of the actin cytoskeleton as well as other adaptor proteins involved in receptor tyrosine kinase (RTK) signaling. These interactions enable CIN85/CMS to function within a network of signaling pathways that co‐ordinate critical steps involved in downregulation and degradation of RTKs.