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PIAS3 (protein inhibitor of activated STAT‐3) modulates the transcriptional activation mediated by the nuclear receptor coactivator TIF2
Author(s) -
Jiménez-Lara Ana M.,
Heine Mattias J.S.,
Gronemeyer Hinrich
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(02)03154-x
Subject(s) - coactivator , nuclear receptor coactivator 3 , nuclear receptor , nuclear receptor coactivator 2 , pelp 1 , nuclear receptor coactivator 1 , receptor , chemistry , transcription (linguistics) , microbiology and biotechnology , transcription factor , biology , biochemistry , gene , linguistics , philosophy
PIAS3, a member of the protein inhibitor of activated STAT family, was found to interact in vivo and in vitro with TIF2, a previously described coactivator for nuclear receptors. The interaction is mediated by two distinct non‐contiguous regions of TIF2. We found that TIF2–PIAS3 interaction occurs through a unique domain of PIAS3, very rich in acidic residues and conserved throughout the PIAS family. PIAS3 modulates the ability of TIF2 to mediate ligand‐enhanced transcription activation positively or negatively, for different steroid receptors. Taken together, our results indicate a potential role of PIAS3 as transcriptional modulator of TIF2‐mediated signalling.