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Only the soluble form of the scavenger receptor CD163 acts inhibitory on phorbol ester‐activated T‐lymphocytes, whereas membrane‐bound protein has no effect
Author(s) -
Frings Werner,
Dreier Jens,
Sorg Clemens
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(02)03142-3
Subject(s) - scavenger receptor , cd163 , microbiology and biotechnology , transfection , chemistry , receptor , phorbol , biology , biochemistry , in vitro , protein kinase c , macrophage , gene , signal transduction , lipoprotein , cholesterol
The extracellular moiety of the hemoglobin/haptoglobin scavenger receptor CD163 (RM3/1 antigen) can be shed from monocytes and is a normal plasma component. We found that in a dose‐dependent manner soluble CD163 induces a decrease in CD69 expression, a reduced [ 3 H]thymidine uptake and a down‐regulated matrix metalloproteinase‐9 RNA expression in phorbol myristate acetate‐stimulated T‐cells. Co‐culturing T‐cells on transgenic fibroblasts, expressing membrane‐bound CD163, yielded no differences compared to culture on non‐transfected cells. We conclude that CD163 has at least two distinct functions: the clearance of hemoglobin in its cell‐bound form and participation in anti‐inflammation as a soluble factor, exhibiting cytokine‐like functions.