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Ring up the curtain on DING proteins
Author(s) -
Berna Anne,
Bernier François,
Scott Ken,
Stuhlmüller Bruno
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(02)03053-3
Subject(s) - biology , receptor , microbiology and biotechnology , phosphatase , biochemistry , computational biology , chemistry , phosphorylation
DING proteins have a characteristic DINGGG‐ or closely related N‐terminal sequence. One is found in human synovial fluid, and may be associated with rheumatoid arthritis. Other examples have receptor or signalling roles in various human and animal cells, or are involved in biomineralisation, and several of them bind to phytochemicals. As plant DING proteins have recently been discovered, we hypothesise that the DING protein‐phytochemical association may represent one aspect of a ubiquitous receptor‐linked signalling system. Several microbial proteins related to DING proteins have phosphatase activity, which may relate to biomineralisation in eukaryotic systems. Plant DING proteins and their microbial relatives may elicit allergic responses leading to arthritic disease.