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The C‐terminus of myogenin, but not MyoD, targets upregulation of MEF2C expression
Author(s) -
Rogerson Parker J,
Jamali Mina,
Skerjanc Ilona S
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(02)03024-7
Subject(s) - myod , myogenin , myogenesis , mef2c , mef2 , ectopic expression , pitx2 , transcription factor , microbiology and biotechnology , myocyte , biology , chemistry , enhancer , genetics , gene , homeobox
The myogenic regulatory family of basic helix‐loop‐helix transcription factors, including MyoD and myogenin, functions cooperatively with the myocyte‐specific enhancer binding factor 2 (MEF2) family during skeletal myogenesis. Previously, using aggregated P19 cells, we have shown that myogenin upregulates MEF2C expression while MyoD does not [Ridgeway et al., J. Biol. Chem. 275 (2000) 41–46]. In order to identify the domain of myogenin responsible for activating MEF2C expression, a series of chimeras of MyoD and myogenin were generated. Only chimeras containing the C‐terminal region of myogenin were able to activate MEF2C in aggregated P19 cells, suggesting that the C‐terminus of myogenin is responsible for the regulation of specific target genes.