Premium
The Aspergillus nidulans cyclin PclA accumulates in the nucleus and interacts with the central cell cycle regulator NimX Cdc2
Author(s) -
Schier Niklas,
Fischer Reinhard
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(02)02964-2
Subject(s) - aspergillus nidulans , regulator , cyclin dependent kinase 1 , cyclin b1 , nucleus , microbiology and biotechnology , cell cycle , chemistry , biology , cell , biochemistry , gene , mutant
The filamentous fungus Aspergillus nidulans reproduces asexually through conidiospores, which are continuously generated at morphologically differentiated structures, the conidiophores. In contrast to vegetative, multinucleate cells, spore formation requires a strict coordination of mitosis and cytokinesis. It was shown recently that the key regulator of the cell cycle in A. nidulans NimX Cdc2 and a G 1 /S cyclin, PclA, are transcriptionally upregulated during development. Here we show that PclA accumulates in the nucleus and interacts with NimX Cdc2 . We propose that PclA modulates the kinase activity of NimX Cdc2 during spore formation.