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Different roles of the IGF‐I Ec peptide (MGF) and mature IGF‐I in myoblast proliferation and differentiation
Author(s) -
Yang Shi Yu,
Goldspink Geoffrey
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(02)02918-6
Subject(s) - growth factor , receptor , microbiology and biotechnology , myocyte , function (biology) , cell growth , chemistry , peptide , insulin like growth factor , in vitro , cellular differentiation , biology , biochemistry , gene
The physiological function of a recently cloned splice variant of insulin‐like growth factor‐I (IGF‐I; mechano growth factor (MGF)) was studied using an in vitro cell model. Unlike mature IGF‐I, the distinct E domain of MGF inhibits terminal differentiation whilst increasing myoblast proliferation. Blocking the IGF‐I receptor with a specific antibody indicated that the function of MGF E domain is mediated via a different receptor. The results provide a basis for localized tissue adaptation and helps explain why loss of muscle mass occurs in the elderly and in dystrophic muscle in which MGF production is markedly affected.