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The expression of native and oxidized LDL receptors in brain microvessels is specifically enhanced by astrocytes‐derived soluble factor(s)
Author(s) -
Lucarelli Marco,
Borrelli Valeria,
Fiori Anna,
Cucina Alessandra,
Granata Filippo,
Potenza Rosa Luisa,
Scarpa Sigfrido,
Cavallaro Antonino,
Strom Roberto
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(02)02857-0
Subject(s) - receptor , astrocyte , microbiology and biotechnology , lrp1 , heterologous , chemistry , blood–brain barrier , isolated brain , ldl receptor , biology , lipoprotein , biochemistry , central nervous system , neuroscience , cholesterol , gene
Ex vivo rat brain microvessels express receptors for native as well as for oxidized low‐density lipoproteins. In brain microvessels‐derived endothelial cells, the expression levels of both receptors were enhanced by co‐cultivation with rat astrocytes, even in the absence of actual contact between the two cell types, suggesting a soluble factor(s)‐based mechanism of induction. No modulation effect could be evidenced in a heterologous cellular system. Since both receptors were found to be expressed also in astrocytes, these cells are likely to contribute substantially to the lipoprotein management at the blood–brain barrier and in the brain compartment.