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Targeted disruption of LIG‐1 gene results in psoriasiform epidermal hyperplasia 1
Author(s) -
Suzuki Yutaka,
Miura Hiroyuki,
Tanemura Atsushi,
Kobayashi Kinji,
Kondoh Gen,
Sano Shigetoshi,
Ozawa Kentaro,
Inui Shigeki,
Nakata Aya,
Takagi Tsutomu,
Tohyama Masaya,
Yoshikawa Kunihiko,
Itami Satoshi
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(02)02824-7
Subject(s) - epidermis (zoology) , psoriasis , biology , transmembrane protein , microbiology and biotechnology , leucine rich repeat , gene , extracellular , cancer research , immunology , genetics , anatomy , receptor
The gene encoding a transmembrane glycoprotein LIG‐1, of which the extracellular region was organized with the leucine‐rich repeats and immunoglobulin‐like domains, was disrupted in mice by gene targeting. LIG‐1‐deficient mice developed a skin change on the tail and facial area after birth. The affected skin was histologically reminiscent of the epidermis in human common skin disease ‘psoriasis’. LIG‐1 was expressed in basal cells of the epidermis and outer root sheath cells of hair follicles in mice. Interestingly, the LIG‐1 expression was apparently down‐regulated in the psoriatic lesions, suggesting that LIG‐1 inversely correlates with proliferative ability of epidermal keratinocytes.