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The LIM domain protein Lmo2 binds to AF6, a translocation partner of the MLL oncogene
Author(s) -
Bégay-Müller Valérie,
Ansieau Stéphane,
Leutz Achim
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(02)02814-4
Subject(s) - lim domain , fusion protein , biology , oncogene proteins , chromosomal translocation , haematopoiesis , chromatin remodeling , microbiology and biotechnology , gene , chromatin , transcription factor , cancer research , genetics , regulation of gene expression , zinc finger , stem cell , recombinant dna
The LIM only protein Lmo2 plays an important role in hematopoiesis and leukemogenesis. Lmo2 acts as a bridging molecule between components of hematopoietic gene regulatory protein complexes. We used the yeast two‐hybrid system to identify novel Lmo2 interacting proteins and found that the AF6 protein binds to Lmo2. AF6 is a recurrent fusion partner of MLL, the human homolog of Drosophila trithorax chromatin remodeling protein that is involved in childhood leukemia and mixed lineage leukemia. Our data support the notion that recurrent fusion partners of chimeric MLL proteins recruit hematopoietic gene regulatory complexes.