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Short‐time non‐enzymatic nitric oxide synthesis from L ‐arginine and hydrogen peroxide induced by shock waves treatment
Author(s) -
Gotte G.,
Amelio E.,
Russo S.,
Marlinghaus E.,
Musci G.,
Suzuki H.
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(02)02807-7
Subject(s) - hydrogen peroxide , nitric oxide , arginine , kinetics , enzyme , chemistry , shock (circulatory) , shock wave , biochemistry , oxide , biophysics , medicine , organic chemistry , biology , amino acid , physics , quantum mechanics , thermodynamics
The evidence that nitric oxide (NO) production is possible by a non‐enzymatic pathway has already been shown under restrictive experimental conditions. Here we show that NO can non‐enzymatically be formed with short‐time kinetics (min), by ‘bombing’ with shock waves a solution containing 1 mM hydrogen peroxide and 10 mM L ‐arginine. This procedure is widening its medical application with surprisingly positive effects in tissue regeneration and our finding could be one of the first steps for the understanding of the biochemical responsible for these therapeutical effects.