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Identification of G protein‐coupled receptor genes from the human genome sequence
Author(s) -
Takeda Shigeki,
Kadowaki Shiro,
Haga Tatsuya,
Takaesu Hirotomo,
Mitaku Shigeki
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(02)02775-8
Subject(s) - g protein coupled receptor , human genome , receptor , biology , intron , gene , rhodopsin like receptors , genome , computational biology , genetics , metabotropic receptor , glutamate receptor
We have identified novel G protein‐coupled receptors (GPCRs) with no introns in the coding region from the human genome sequence: 322 olfactory receptors; 22 taste receptors; 128 registered GPCRs for endogenous ligands; 50 novel GPCR candidates homologous to registered GPCRs for endogenous ligands; and 59 novel GPCR candidates not homologous to registered GPCRs. The total number of GPCRs with and without introns in the human genome was estimated to be approximately 950, of which 500 are odorant or taste receptors and 450 are receptors for endogenous ligands.