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The LGI1 gene involved in lateral temporal lobe epilepsy belongs to a new subfamily of leucine‐rich repeat proteins
Author(s) -
Gu Wenli,
Wevers Andrea,
Schröder Hannsjörg,
Grzeschik Karl-Heinz,
Derst Christian,
Brodtkorb Eylert,
de Vos Rob,
Steinlein Ortrud K
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(02)02713-8
Subject(s) - subfamily , epileptogenesis , biology , gene , genetics , in silico , transmembrane protein , leucine rich repeat , temporal lobe , epilepsy , neuroscience , receptor
Recently mutations in the LGI1 (leucine‐rich, glioma‐inactivated 1) gene have been found in human temporal lobe epilepsy. We have now identified three formerly unknown LGI‐like genes. Hydropathy plots and pattern analysis showed that LGI genes encode proteins with large extra‐ and intracellular domains connected by a single transmembrane region. Sequence analysis demonstrated that LGI1, LGI2, LGI3, and LGI4 form a distinct subfamily when compared to other leucine‐rich repeat‐containing proteins. In silico mapping and radiation hybrid experiments assigned LGI2, LGI3, and LGI4 to different chromosomal regions (4p15.2, 8p21.3, 19q13.11), some of which have been implicated in epileptogenesis and/or tumorigenesis.