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Cooperative repression of cyclin‐dependent kinase inhibitor p21 gene expression by hepatitis B virus X protein and hepatitis C virus core protein
Author(s) -
Han Hae Jin,
Jung Eun Young,
Lee Woo Jung,
Jang Kyung Lib
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(02)02694-7
Subject(s) - virology , hepatitis b virus , viral transformation , hepatitis b virus dna polymerase , microbiology and biotechnology , hepatitis b virus pre beta , ns2 3 protease , psychological repression , virus , chemistry , hepatitis c virus , gene , gene expression , biology , cancer research , biochemistry
Co‐infection with hepatitis B virus (HBV) and hepatitis C virus (HCV) is common and is associated with a more severe liver disease and increased frequency in the development of hepatocellular carcinoma (HCC). Here, we demonstrated that HBV X protein (HBx) and HCV core protein additively repress the universal cyclin‐dependent kinase inhibitor p21 gene at the transcription level. The transforming growth factor‐β responsive element and Sp1 site of the p21 promoter were responsible for the effect of HCV core and HBx, respectively. Furthermore, cell growth was additively stimulated by them, suggesting that additive repression of the p21 might be important to understand the cooperative development of HCC by HBV and HCV.