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The presence of 4‐hydroxyphenylacetic acid in human saliva and the possibility of its nitration by salivary nitrite in the stomach
Author(s) -
Takahama Umeo,
Oniki Takayuki,
Murata Hideaki
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(02)02659-5
Subject(s) - saliva , nitrite , chemistry , sodium nitrite , nitration , stomach , human stomach , dietary nitrate , biochemistry , food science , nitrate , organic chemistry
Human saliva contained 4‐hydroxyphenylacetic acid (HPA) (2–10 μM) and nitrite (60–300 μM). HPA was nitrated to 4‐hydroxy‐3‐nitrophenylacetic acid (NO 2 HPA) when HPA and sodium nitrite were mixed at pH 1.0. NO 2 HPA was also formed when saliva was incubated under acidic conditions. These results suggest that salivary HPA is nitrated to NO 2 HPA when saliva is swallowed into the stomach.