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Latent TGF‐β binding protein‐3 (LTBP‐3) requires binding to TGF‐β for secretion
Author(s) -
Chen Yan,
Dabovic Branka,
Annes Justin P,
Rifkin Daniel B
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(02)02648-0
Subject(s) - secretion , transforming growth factor , transforming growth factor beta , protein precursor , tgf beta signaling pathway , binding protein , secretory protein , chemistry , microbiology and biotechnology , biology , biochemistry , gene
Latent transforming growth factor‐β (TGF‐β) binding protein (LTBP)‐1, which is easily secreted, has been shown to enhance the secretion of TGF‐β. Here we show that another member of the LTBP family, LTBP‐3, is not secreted by several cell types, but secretion occurs after coexpression with TGF‐β. The secretion of LTBP‐3 requires complexing of LTBP‐3 with Cys33 of the TGF‐β propeptide.