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Zinc is required for structural stability of the C‐terminus of archaeal translation initiation factor aIF2β
Author(s) -
Gutiérrez Pablo,
Coillet-Matillon Stéphane,
Arrowsmith Cheryl,
Gehring Kalle
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(02)02610-8
Subject(s) - zinc finger , eukaryotic translation , translation (biology) , start codon , initiation factor , eukaryotic initiation factor , eif4a1 , eukaryotic translation initiation factor 4 gamma , chemistry , biology , microbiology and biotechnology , genetics , computational biology , biochemistry , messenger rna , gene , transcription factor
aIF2β is an archaeal homolog of eukaryotic translation factor eIF2β necessary for translation initiation and involved in recognition of the initiation codon. In the present study, we demonstrate for the first time zinc binding to the C 2 –C 2 zinc finger at the C‐terminus of aIF2β. Nuclear magnetic resonance backbone assignments were also determined and the secondary structural elements identified.