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Mild heat shock induces cyclin D1 synthesis through multiple Ras signal pathways
Author(s) -
Han Song Iy,
Oh Su Young,
Jeon Won Je,
Kim Jung Mo,
Lee Jun Hyuk,
Chung Hae Young,
Choi Yung Hyun,
Yoo Mi Ae,
Kim Han Do,
Kang Ho Sung
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(02)02459-6
Subject(s) - cyclin d1 , microbiology and biotechnology , cyclin d , phosphatidylinositol , signal transduction , kinase , cyclin , cell growth , cell cycle , cyclin a , cancer research , biology , chemistry , cell , biochemistry
Hyperthermia such as that occurring during fever may improve cell survival during infection, although its mechanism of action is largely unknown. Here we show that acute exposure to mild, but not severe, heat shock induces the synthesis of cyclin D1 that plays a critical role(s) in G1 progression of the cell cycle. This induction seemed to be regulated through multiple Ras signal pathways involving extracellular signal‐regulated kinase, phosphatidylinositol 3‐kinase, and Rac1/NADPH oxidase, all of which have well been documented to be responsible for growth factor‐induced cyclin D1 expression. In a physiological sense, mild heat shock may regulate cell proliferation through inducing cyclin D1 along with growth factors.