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The allograft inflammatory factor‐1 family of proteins
Author(s) -
Deininger Martin H,
Meyermann Richard,
Schluesener Hermann J
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(02)02430-4
Subject(s) - interferon , interferon gamma , interferon regulatory factors , alternative splicing , biology , genetics , computational biology , microbiology and biotechnology , immunology , transcription factor , exon , medicine , cytokine , gene
The allograft inflammatory factor‐1 (AIF‐1) is a 17 kDa interferon‐γ‐inducible Ca 2+ ‐binding EF‐hand protein that is encoded within the HLA class III genomic region. Three proteins are probably identical with AIF‐1 termed Iba1 (ionized Ca 2+ ‐binding adapter), MRF‐1 (microglia response factor) and daintain. Considerable but not complete sequence identity with AIF‐1 has been described for IRT‐1 (interferon‐responsive transcript), BART‐1 (balloon angioplasty‐responsive transcript), and other, yet unassigned alternatively spliced variants. In this review, genomic and functional characteristics of AIF‐1‐related proteins are summarized and a common nomenclature is proposed.