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Genome‐wide studies on the nuclear PDR3‐controlled response to mitochondrial dysfunction in yeast
Author(s) -
Devaux Frédéric,
Carvajal Elvira,
Moye-Rowley Scott,
Jacq Claude
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(02)02387-6
Subject(s) - biology , yeast , mitochondrial dna , mitochondrion , saccharomyces cerevisiae , gene , nuclear gene , inner mitochondrial membrane , genetics , microbiology and biotechnology
Gain‐of‐function mutations in the transcription factors Pdr1p and Pdr3p lead to the up‐regulation of genes controlling plasma membrane properties. Pdr3p is involved in a retrograde response in which mitochondrial dysfunctions activate PDR5 , a gene encoding an ABC membrane transporter. We carried out genome‐wide analyses of the PDR3 ‐controlled genes activated by the deletion of the mitochondrial DNA. We present evidence showing that PDR1 does not interfere with this PDR3 response. We also showed that the mitochondrially activated PDR3 response is highly sensitive to both yeast strain variations and carbon sources. These observations explain the apparent discrepancies in published studies and better describe the connections between the mitochondrial state and plasma membrane properties.