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Translocation of tRNA during protein synthesis
Author(s) -
Noller Harry F.,
Yusupov Marat M.,
Yusupova Gulnara Z.,
Baucom Albion,
Cate J.H.D.
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(02)02327-x
Subject(s) - chromosomal translocation , ribosome , transfer rna , protein biosynthesis , translation (biology) , messenger rna , t arm , chemistry , computational biology , mechanism (biology) , microbiology and biotechnology , biology , biochemistry , rna , physics , gene , quantum mechanics
Coupled translocation of tRNA and mRNA in the ribosome during protein synthesis is one of the most challenging and intriguing problems in the field of translation. We highlight several key questions regarding the mechanism of translocation, and discuss possible mechanistic models in light of the recent crystal structures of the ribosome and its subunits.