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Malignant transformation by the eukaryotic translation initiation factor 3 subunit p48 (eIF3e)
Author(s) -
Mayeur Greg L,
Hershey John W.B
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(02)02307-4
Subject(s) - eif4e , initiation factor , eukaryotic translation , translation (biology) , protein subunit , transformation (genetics) , malignant transformation , biology , eif4ebp1 , microbiology and biotechnology , gene , messenger rna , genetics
Several components of translation, e.g. eIF4E and PKR, are implicated in cancer. The e‐subunit (p48) of mammalian initiation factor 3 is encoded by the Int6 gene, a common site for integration of the mouse mammary tumor virus genome, leading to the production of a truncated eukaryotic initiation factor‐3e (eIF3e). Stable expression of a truncated eIF3e in NIH 3T3 cells causes malignant transformation by four criteria: foci formation; anchorage independent growth; accelerated growth; and lack of contact inhibition. Stable expression of full‐length eIF3e does not cause transformation. The truncated eIF3e also inhibits the onset of apoptosis caused by serum starvation.