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The phosphatidylinositol 3‐phosphate‐binding FYVE finger
Author(s) -
Stenmark Harald,
Aasland Rein,
Driscoll Paul C.
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)03308-7
Subject(s) - phosphatidylinositol , endosome , zinc finger , microbiology and biotechnology , chemistry , cytosol , yeast , biochemistry , membrane , membrane protein , biology , signal transduction , receptor , enzyme , transcription factor , gene
The FYVE zinc finger domain is conserved from yeast (five proteins) to man (27 proteins). It functions in the membrane recruitment of cytosolic proteins by binding to phosphatidylinositol 3‐phosphate (PI3P), which is found mainly on endosomes. Here we review recent work that sheds light on the targeting of FYVE finger proteins to PI3P‐containing membranes, and how these proteins serve to regulate multiple cellular functions.