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The FHA domain
Author(s) -
Durocher Daniel,
Jackson Stephen P.
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)03294-x
Subject(s) - kinase , microbiology and biotechnology , transcription factor , phosphatase , transcription (linguistics) , protein domain , biology , biochemistry , chemistry , phosphorylation , computational biology , gene , linguistics , philosophy
The forkhead‐associated (FHA) domain is a small protein module recently shown to recognize phosphothreonine epitopes on proteins. It is present in a diverse range of proteins in eukaryotic cells, such as kinases, phosphatases, kinesins, transcription factors, RNA‐binding proteins, and metabolic enzymes. It is also found in a number of bacterial proteins. This suggests that FHA domain‐mediated phospho‐dependent assembly of protein complexes is an ancient and widespread regulatory mechanism.