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VHS domain – a longshoreman of vesicle lines
Author(s) -
Lohi Olli,
Poussu Anssi,
Mao Yuxin,
Quiocho Florante,
Lehto Veli-Pekka
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)03287-2
Subject(s) - golgi apparatus , superhelix , chemistry , domain (mathematical analysis) , vesicle , docking (animal) , microbiology and biotechnology , transport protein , biophysics , biochemistry , biology , membrane , endoplasmic reticulum , dna supercoil , medicine , dna , mathematical analysis , dna replication , mathematics , nursing
The VHS ( ps‐27, rs and TAM) domain is a 140 residue long domain present in the very NH 2 ‐terminus of at least 60 proteins. Based on their functional characteristics and on recent data on the involvement of VHS in cargo recognition in trans‐Golgi, VHS domains are considered to have a general membrane targeting/cargo recognition role in vesicular trafficking. Structurally, VHS is a right‐handed superhelix of eight helices with charged surface patches probably serving as sites of protein–protein recognition and docking.