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Uncoupling proteins outside the animal and plant kingdoms: functional and evolutionary aspects
Author(s) -
Sluse Francis E.,
Jarmuszkiewicz Wieslawa
Publication year - 2002
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)03229-x
Subject(s) - oxidative phosphorylation , alternative oxidase , mitochondrion , electron transport chain , intracellular , respiration , microbiology and biotechnology , uncoupling agents , respiratory chain , uncoupling protein , biochemistry , cellular respiration , redox , biophysics , biology , chemistry , botany , adipose tissue , brown adipose tissue , organic chemistry
The appearance of intracellular oxidative phosphorylation at the time of acquisition of mitochondria in Eukarya was very soon accompanied by the emergence of uncoupling protein, a carrier specialized in free fatty acid‐mediated H + recycling that can modulate the tightness of coupling between mitochondrial respiration and ATP synthesis, thereby maintaining a balance between energy supply and demand in the cell and defending cells against damaging reactive oxygen species production when electron carriers of the respiratory chain become overreduced. The simultaneous occurrence of redox free energy‐dissipating oxidase, which has the same final effect, could be related to the functional interactions between both dissipative systems.