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A new family of CoA‐transferases
Author(s) -
Heider Johann
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)03178-7
Subject(s) - transferase , enzyme , biochemistry , biology , archaea , carnitine , acyl coa , gene
CoA‐transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well‐known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA‐transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA‐transferases of the other families. Currently known enzymes of the new family are a formyl‐CoA: oxalate CoA‐transferase, a succinyl‐CoA: ( R )‐benzylsuccinate CoA‐transferase, an ( E )‐cinnamoyl‐CoA: ( R )‐phenyllactate CoA‐transferase, and a butyrobetainyl‐CoA: ( R )‐carnitine CoA‐transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA‐transferases of family III are described and compared to those of the previously known CoA‐transferases.