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A novel second myostatin gene is present in teleost fish
Author(s) -
Maccatrozzo Lisa,
Bargelloni Luca,
Cardazzo Barbara,
Rizzo Giorgia,
Patarnello Tomaso
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)03124-6
Subject(s) - biology , gene , complementary dna , myostatin , metamorphosis , phylogenetic tree , larva , peptide sequence , genetics , ecology
We report on the isolation and characterisation of the complete cDNA sequence encoding a novel bone morphogenetic protein‐like protein (sbMSTN‐b) in the teleost fish Sparus aurata . The encoded protein is 68% identical to S. aurata MSTN at the amino acid level, and homologues were also found in Umbrina cirrosa and Tetraodon nigroviridis . Phylogenetic analysis suggests that the MSTN‐b gene may be present in most, perhaps all, teleost fish species. RT‐PCR on different tissues/stages indicates that MSTN‐b is expressed almost exclusively in the central nervous system, starting from late larval stages. Quantitative analyses indicate an increase of sbMSTN‐b expression in the brain associated with metamorphosis, at the same time as completion of nervous system differentiation.