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S ‐Adenosyl‐ L ‐homocysteine hydrolase is sequestered into actin rods in Dictyostelium discoideum spores
Author(s) -
Kishi Yoshiro,
Sugo Teruko,
Mahadeo Dana,
Cotter David,
Sameshima Masazumi
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)03105-2
Subject(s) - dictyostelium discoideum , dictyostelium , microbiology and biotechnology , actin , cytoskeleton , biology , chemistry , biochemistry , cell , gene
Here we show evidence that S ‐adenosyl‐ L ‐homocysteine hydrolase (SAHH) is linked to the actin cytoskeleton. Actin rods formed in Dictyostelium discoideum spores during the final stage of development are structurally composed of novel bundles of actin filaments. SAHH only accumulates with actin at this stage of development in the life cycle of D. discoideum . Recently SAHH is believed to be a target for antiviral chemotherapy and the suppression of T cells. Our finding may contribute to designing novel antiviral and immunosuppressive drugs.