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The Arabidopsis thaliana ethylene‐responsive element binding protein (AtEBP) can function as a dominant suppressor of Bax‐induced cell death of yeast
Author(s) -
Pan Ling,
Kawai Maki,
Yu Li-Hua,
Kim Kyung-Min,
Hirata Aiko,
Umeda Masaaki,
Uchimiya Hirofumi
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)03098-8
Subject(s) - arabidopsis , programmed cell death , arabidopsis thaliana , microbiology and biotechnology , biology , suppressor , complementary dna , cdna library , yeast , function (biology) , gene , genetics , apoptosis , mutant
We identified genes based on screening of an Arabidopsis cDNA library for functional suppressors of mouse Bax‐induced cell death of yeast cells. Interestingly, the cDNA encoding AtEBP, known as Arabidopsis thaliana ethylene‐responsive element binding protein, was isolated numerous times in the functional screen (82% of all suppressors). Full‐length AtEBP and its localization to the nucleus were essential for the suppression of Bax‐induced cell death. Morphological abnormality of intracellular network that is a hallmark of Bax‐induced cell death was attenuated by expression of AtEBP.