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CD30L up‐regulates CD30 and IL‐4 expression by T cells
Author(s) -
Rossi Francesca Maria,
Degan Massimo,
Mazzocut-Zecchin Linda,
Di Francia Raffaele,
Aldinucci Donatella,
Pinto Antonio,
Gattei Valter
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)03076-9
Subject(s) - cd30 , immune system , t cell , biology , microbiology and biotechnology , chemistry , cancer research , immunology , tumor cells
CD30L is frequently expressed on acute myeloid leukemia (AML) blasts. Its presence is associated with the co‐expression of interleukin‐4 (IL‐4) receptor and with the expansion of specific T‐helper 2 (Th2) cell subsets producing IL‐4 and expressing CD30. Recombinant CD30L‐bearing cells up‐regulated the expression of surface CD30 and increased the production of IL‐4 and soluble (s) CD30 by co‐cultured T cells. These findings were confirmed with AML blasts expressing surface CD30L, where blocking anti‐CD30 antibodies completely abolished the release of sCD30 and reduced the production of IL‐4. Our data indicates a direct role of CD30L + neoplastic cells in driving the immune response toward a Th2‐polarized non‐protective state.