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Myosin VI, a new force in clathrin mediated endocytosis
Author(s) -
Buss Folma,
Luzio J.Paul,
Kendrick-Jones John
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)03065-4
Subject(s) - endocytosis , myosin , clathrin , microbiology and biotechnology , actin , receptor mediated endocytosis , cytoskeleton , actin cytoskeleton , motor protein , chemistry , biology , biophysics , receptor , biochemistry , cell , microtubule
The integrity of the actin cytoskeleton and associated motor proteins are essential for the efficient functioning of clathrin mediated endocytosis at least in polarised cells. Myosin VI, the only motor protein so far identified that moves towards the minus end of actin filaments, is the first motor protein to be shown to associate with clathrin coated pits/vesicles at the plasma membrane and to modulate clathrin mediated endocytosis. Recent kinetic studies suggest that myosin VI may move processively along actin filaments providing clues about its functions in the cell. The possible role(s) of myosin VI in the sequential steps involved in receptor mediated endocytosis are discussed.