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Nuclear translocation of PDCD5 (TFAR19): an early signal for apoptosis?
Author(s) -
Chen Yingyu,
Sun Ronghua,
Han Wenling,
Zhang Yingmei,
Song Quansheng,
Di Chunhui,
Ma Dalong
Publication year - 2001
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/s0014-5793(01)03062-9
Subject(s) - apoptosis , phosphatidylserine , microbiology and biotechnology , cytoplasm , dna fragmentation , programmed cell death , fragmentation (computing) , chromosomal translocation , biology , nucleus , cell nucleus , cell , genetics , gene , membrane , phospholipid , ecology
The programmed cell death 5 (PDCD5) protein is a novel protein related to regulation of cell apoptosis. In this report, we demonstrate that the level of PDCD5 protein expressed in cells undergoing apoptosis is significantly increased compared with normal cells, then the protein translocates rapidly from the cytoplasm to the nucleus of cells. The appearance of PDCD5 in the nuclei of apoptotic cells precedes the externalization of phosphatidylserine and fragmentation of chromosome DNA. This phenomenon is parallel to the loss of mitochondrial membrane potential, independent of the feature of apoptosis‐inducing stimuli and also independent of the cell types and the apoptosis modality. In conclusion, the nuclear translocation of PDCD5 is a universal earlier event of the apoptotic process, and may be a novel early marker for apoptosis.